DAMPs refer to the cellular debris or damage that results from being attacked.Ģ. PAMPs are substances that can be recognized by specialized receptors, such as Toll-like receptor (TLR), NOD-like receptor (NLR), and RIG-I like helicases (RLH). Detection: Detection of PAMPs (e.g., pathogen-associated molecular patterns like lipopolysaccharides) or damage-associated molecular patterns (DAMPs). The danger response cascade can be broken up into five steps that occur in succession:ġ. The activated CDR will then enter into a cascade – this is where it gets its name, the danger response cascade (DRC). When these substances get leaked into the extracellular environment, CDR kicks into gear. This danger can also come in the form of molecules such as DNA, RNA, and proteins – all of which are components found inside our cells. CDR is a mechanism that allows cells to sense ‘danger’ that may be caused by viruses or bacteria. When CDR is activated, the body will use available energy sources and switch its focus to self-defense rather than growth and reproduction. How it works is by the cell senses that it is being attacked, then using specialized proteins to monitor our metabolism. The cell danger response (CDR) is the evolutionarily conserved metabolic response that protects cells and hosts from harm. In this week’s blog post we will not only explain what CDR is but also how we minimize its risks so we may live a healthy life. Yet CDR can be dangerous if it overreacts and causes inflammation – which can lead to chronic diseases such as diabetes or even cancer.

In the case of cell danger response (CDR), our cells do their best to protect themselves as they are being attacked by viruses or bacteria. It does this by recognizing invaders through amazing sensing mechanisms and responding to them with incredible precision. The body’s immune system is a complicated, elegant machine that protects us from the outside world.

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